Bhussry Seminar Series: “DNA End Resection: Cutting Away Nucleotides to Maintain Genomic Integrity”
Presentation: “DNA End Resection: Cutting Away Nucleotides to Maintain Genomic Integrity”
Speaker:
Hardeep Kaur, PhD
Research Scientist-Senior
Department of Biochemistry and Structural Biology
University of Texas, Health Science Center
San Antonio, Texas
Presented via Zoom only.
About This Seminar:
DNA Double strand breaks (DSB) are repaired by Homologous recombination (HR) or Non homologous end joining (NHEJ) and a balance between two pathways is essential for genome stability. Tumor suppressor complex “BRCA1-BARD1’’ is indispensable for the timely resection of DNA ends to create 3’ single-stranded DNA and commits DSB repair by HR. BRCA1-BARD1 directly interacts with and promotes EXO1 and BLM/WRN-DNA2 mediated DNA end resection. Both BRCA1 and BARD1 harbors standalone functional modules in the form of their DNA binding domains to ensure the overall efficacy of BRCA1-BARD1 as a positive regulator of DNA end resection. BRCA1-BARD1 serves a direct, multifaceted role in DNA end resection and hence in regulating DNA repair pathway choice in human cells.
Sponsored by the Department of Biochemistry and Molecular & Cellular Biology