Lecture, Research

Distinguished Scientist Seminar Series featuring Jonathan Brestoff, MD, PhD – “Mitochondria on the Move: Mitochondria Transfer in Metabolic Diseases”

Name: Distinguished Scientist Seminar Series featuring Jonathan Brestoff, MD, PhD – “Mitochondria on the Move: Mitochondria Transfer in Metabolic Diseases”
Start: 2024-12-05T16:00:00-05:00
End: 2024-12-05T17:00:00-05:00
Location: Hybrid – New Research Building Auditorium & via Zoom

Distinguished Scientist Seminar Series

Jonathan Brestoff, MD, PhD
Associate Professor of Pathology & Immunology
Director, Initiative for Immunometabolism
Medical Director, Clinical Flow Cytometry Laboratory
Washington University in St. Louis

Location: New Research Building Auditorium and via Zoom (https://georgetown.zoom.us/j/95197826709)

Title & Abstract:

“Mitochondria on the Move: Mitochondria Transfer in Metabolic Diseases”

Over the past 20 years, it has become clear that many cell types have the ability to deliver some of their mitochondria to developmentally unrelated cells in a process that is called “mitochondria transfer.” In this presentation, I will describe the mechanisms of mitochondria transfer and demonstrate how this process regulates white adipose tissue homeostasis and brown fat function in vivo. In addition, I will describe a mitochondria transfer-based therapeutic modality called “mitochondria transplantation” that ameliorates disease progression in a mouse model of Leigh Syndrome.