Joint Distinguished Scientist Seminar Series and Scientific Partners Distinguished Lecture Series featuring Stephen Lockett, PhD – “Understanding Immune Suppression and Invasion in Tumors”

Joint

Distinguished Scientist Seminar Series and

Scientific Partners Distinguished Lecture Series

Stephen Lockett, PhD
Director, Optical Microscopy and Analysis Laboratory
Frederick National Laboratory for Cancer Research

Title & Abstract:

“Understanding Immune Suppression and Invasion in Tumors”

Chronic inflammation has an immune-suppressive role in solid tumors. Therefore, we are understanding the molecular mechanisms of inflammation driven by the nitric oxide / Nos2 pathway, and building a suite of technologies for spatially profiling the molecular characteristics of tumor tissue and live cell models of cancers, so that we can understand the mechanisms that give rise to immune-suppression tumor and how it affects therapy efficacy. Specifically, we use multiplex immunofluorescence to phenotype tumor sections at the single cell level, utilize a unique cell culture chamber to replicate the gradients of hypoxia and nutrients that universally exist in solid tumors and develop new technologies to analyze thick (> 50 µm) tissue sections using 3D imaging.